STUDY OF THE DIFFUSION KINETICS OF DICLOFENAC SODIUM FROM CARBOMER-BASED HYDROGEL AND ORGANOGEL MATRICES

Abstract

This article presents the results of a study devoted to investigating the diffusion and physicochemical properties of gel matrix ointments prepared on the basis of carbopol and sodium carboxymethyl cellulose (Na-CMC). The advantages of topical dosage forms, their direct effect on the affected area, and their ability to reduce systemic side effects are scientifically substantiated. The research aimed to obtain an effective bio-compatible, viscous, and highly diffusive matrix by introducing Na-CMC into hydrogel and organogel compositions to reduce the amount of carbopol. The diffusion kinetics of diclofenac sodium released from the polymer matrix were studied using the Franz diffusion cell method. Based on the obtained UV–vis spectrum results, the absorbance at a wavelength of 276 nm was determined, and a linear equation (A=0.0036C–0.0031) with a high correlation coefficient (R²=0.9875) was established. These results reveal the potential for compositional optimization of gel-based drugs and hold significant practical importance in the development of pharmaceutical ointment formulations.